Calciphylaxis

Image and content excerpted from the VisualDx clinical decision support system.


Image of Calciphylaxis

VisualDx images show variation in age, skin color, and disease stage. VisualDx has 50 images of Calciphylaxis.

Full text and additional images for Calciphylaxis are available in the following VisualDx packages:

Pediatrics Complete

See descriptions of all packages available or sign up for a Free 30-Day Trial of the Essentials Package.


ICD Codes

ICD-9-CM:
275.40 – Unspecified disorder of calcium metabolism

ICD-10-CM:
E83.59 – Other disorders of calcium metabolism

Synopsis

Calciphylaxis is the diffuse deposition of insoluble calcium salts in the skin due to systemic dysregulation of calcium metabolism. Disorders of calcium metabolism can be broadly categorized into 4 main groups: dystrophic, metastatic, idiopathic, and iatrogenic. Calciphylaxis is the most severe form of metastatic calcification and is most commonly associated with chronic renal failure, patients on hemodialysis, and secondary hyperparathyroidism.

While the exact pathogenesis is unclear, characteristic pathologic findings include progressive medial calcification of cutaneous blood vessels and subsequent ischemic necrosis of the skin. In addition, the process is believed to be triggered by chronic hypocalcemia from decreased intestinal absorption of calcium; this leads to increased levels of parathyroid hormone (PTH) and subsequent recruitment of calcium and phosphate from bone.

Painful, violaceous patches are initially seen clinically, followed by necrosis, ulcers, and/or gangrene. Mortality from calciphylaxis is high (60%-87%) and is secondary to sepsis from large, nonhealing ulcers.

Risks for developing calciphylaxis include female sex, diabetes, obesity, and calcium-based phosphate binders. The condition has also been observed in patients with breast cancer treated with chemotherapy, systemic lupus erythematosus, end-stage liver disease, and Crohn's disease.

Try VisualDx FREE for 30 days

VisualDx is your key to a faster, more accurate diagnosis.

Sign up today and receive a FREE 30-day trial to the VisualDx Essentials Package.

Your VisualDx subscription includes mobile access via our Apple and Android apps.

VisualDx is a web-based clinical decision support system used in over 1,500 hospitals and large clinics. Learn more.

Get your FREE 30-day trial